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YFV-17D replication is inhibited by mSTAT2 but not hSTAT2 in an IFN-α/β-dependent manner. 2fTGH, U6A, or U6A cells stably expressing mSTAT2-FLAG or hSTAT2-FLAG (U6A + mSTAT2-FLAG and U6A + hSTAT2-FLAG, respectively) were infected at an MOI of 1 with either YFV-17D (A) or DENV2 (B). The cells were treated with 100 U/ml IFN-β at 6 h postinfection. The cells were harvested 24 h postinfection and viral titers were measured by plaque assay on BHK-21 cells.
