TABLE 2.

Conservation of 3D^pol L420 sequence and structure^a

Species group	Virus	Thumb α-helixb	PDB	Citation
Enterovirus A	EV-A71	410NTQDHVRSLCLLAWHN425	4IKA	33
Enterovirus B	CVB3	410NTQDHVRSLCLLAWHN425	4K4X	26
Enterovirus C	Polio	409NTQDHVRSLCLLAWHN424	4K4T	26
Enterovirus D	EV-D68	405NTQDHVRSLCYLAWHN420	5XEO	37
Rhinovirus A	HRV-16	408QMQEHVLSLCHLMWHN423	4K50	26
Rhinovirus B	HRV-14	408NTQDHVRSLCMLAWHS423	1XR5	35
Aphthovirus	FMDV	419TIQEKLISVAGLAVHS434	2E9T	19
Cardiovirus	EMCV	411TLSEKLTSITMLAVHS426	4NZO	36

^aModified from Kempf and Barton (34).

^bPolio L420, and corresponding residue in other viruses, in bold.