FIG 3.
Bioluminescence imaging of MRV infection in human cancer xenografts. BALB/c nude mice transplanted with human cancer cell lines A253 (A to C) or IGR-OV1 (D to F) were infected intravenously with 7.0 × 107 PFU of rsT1L or rsT1L-NLuc. At 7 days postinfection, animals were injected with NLuc substrate via the retro-orbital venous sinus and bioluminescence images were obtained using an IVIS. Arrowheads indicate tumors. After observation, the animals were sacrificed and viral titers (B and E) and NLuc activity (C and F) in the lungs, small intestine, and tumors were examined. Data are expressed as the mean ± SD (n = 3).