FIG 1.

Intranasal vaccines adjuvanted with the mast cell-activating adjuvant compound 48/80 or mastoparan 7 induce serum gp120-IgG titers stronger than those induced by cholera toxin or monophospholipid A. C57BL/6 mice (n = 5/group) were vaccinated on days 0, 7, and 21 with 10 μg gp120 and either no adjuvant, 7 μg M7, 15 μg C48/80, 1 μg CT, or 10 μg MPL. Serum was collected on day 35, and gp120-specific IgG titers were determined by ELISA. *, mice receiving vaccines adjuvanted with C48/80 or M7 had significantly higher serum anti-gp120 IgG titers than mice vaccinated with gp120 alone (P = 0.01 and 0.001, respectively). The horizontal lines indicate the geometric mean titers.