FIG 4.

Intranasal, but not rectal or gastric, administration of MVAgp120 induced serum gp120-specific IgG titers. Female New Zealand White rabbits were vaccinated with MVAgp120 by the intramuscular, intranasal, intragastric, or intrarectal route (n = 3 or 4/group) on days 0 and 28. Serum was collected on day 42, and gp120-specific IgG titers were determined by ELISA. Rectal and gastric administration of MVAgp120 resulted in serum gp120-specific titers that were significantly lower than those from i.m. administration (P = 0.01 and 0.008, respectively). The horizontal lines indicate the geometric mean titers.