TABLE 1.
Murine gp120-specific antibody responses after intranasal vaccination
| Day | Antibody | Unadjuvanted |
M7 |
C48/80 |
CT |
MPL |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. responders/total | GMTa | No. responders/total | GMT | No. responders/total | GMT | No. responders/total | GMT | No. responders/total | GMT | ||
| 14 | Serum IgG | 2/5 | 1:33 ± 72 | 5/5 | 1:4,782,969 ± 6b | 5/5 | 1:1,756 ± 5 | 3/5 | 1:729 ± 243 | 4/5 | 1:5,267 ± 187 |
| 35 | Serum IgG | 2/5 | 1:27 ± 45 | 5/5 | 1:129,140,163 ± 5b | 5/5 | 1:22,267,288 ± 19b | 5/5 | 1:142,203 ± 19 | 5/5 | 1:2,474,143 ± 5 |
| Serum IgA | 0/5 | 1:3 ± 1 | 4/5 | 1:2,187 ± 45b | 0/5 | 1:3 ± 1 | 2/5 | 1:22 ± 15 | 1/5 | 1:6 ± 4 | |
| Vaginal IgG | 1/5 | 1:12 ± 3 | 5/5 | 1:588 ± 3b | 5/5 | 1:1,176 ± 7b | 2/5 | 1:21 ± 5 | 4/5 | 1:97 ± 5 | |
| Vaginal IgA | 0/5 | 1:8 ± 1 | 4.5 | 1:74 ± 7b | 1/5 | 1:9 ± 1 | 1/5 | 1:18 ± 6 | 0/5 | 1:8 ± 1 | |
a
GMT, geometric mean titer ± geometric standard deviation factor.
b
Significantly different from mice receiving unadjuvanted gp120.