FIG 6.

MAbs targeting four antigenic sites were broadly neutralizing. Neutralizing breadth of the C18 MAbs was measured using a diverse panel of genotype 1a and 1b HCV pseudoparticles (HCVpps) and genotype 2–6 HCVccs. Percent neutralization of each strain by each MAb at a 50-μg/ml concentration is shown, with HCVpp or HCVcc on the y axis and MAbs arranged from greatest to least neutralizing breadth on the x axis. HCVpp values are averages of two independent experiments, each performed in duplicate. HCVcc values are from a single experiment performed in duplicate. MAb names are color coded according to hierarchical clustering in Fig. 2.