FIG 3.

Whole-genome sequencing of escape variants. Panels A to H show sequence alignments of escape mutations generated by antibodies AC10, AC4, GD12, FA12, AC11, FC3, FC11, and GA3, respectively. The corresponding protein is labeled at the top with the relevant amino acid. Six plaque-purified viruses (numbered 1 to 6) were sequenced, and amino acids are shown in red (mutated) or black (control; CTL). Six plaque-purified wild-type viruses were sequenced in parallel after an identical number of passages in Vero cells. pr, premembrane.