TABLE 1.
Antibody | Heavy chain profilea |
Light chain profilea |
||||||||
---|---|---|---|---|---|---|---|---|---|---|
V gene | J gene | CDR3 sequence | % germ line identity | Isotype | V gene | J gene | CDR3 sequence | % germ line identity | Isotype | |
AC4 | IGHV1-2*06 | IGHJ6*02 | CARDRRSTWYFYYYGMDVW | 99.1 | IgG2 | IGLV2-8*01 | IGLJ2*01 | CSSYAGSNIYVVF | 99.7 | Lambda |
AC10 | IGHV1-2*06 | IGHJ6*02 | CARDRRSSWYYYYYGMDVW | 99.1 | IgG1 | IGLV2-8*01 | IGLJ2*01 | CSSYAGSNNFRVF | 99.1 | Lambda |
AC11 | IGHV5-10-1*01 | IGHJ4*02 | CARLGLTNYFDYW | 98.8 | IgG1 | IGLV3-21*02 | IGLJ1*01 | CQVWDSSSGGVF | 98.4 | Lambda |
AC3 | IGHV1-2*06 | IGHJ4*02 | CARDHYGDSWHYVFDYW | 97.9 | IgG1 | IGKV3-15*01 | IGKJ2*01 | CQQYNNWPRYTF | 97.5 | Kappa |
AD5 | IGHV1-18*01 | IGHJ4*02 | CAREYYDFWSGYYAYYFDYW | 99.7 | IgG1 | IGLV2-14*01 | IGLJ3*02 | CSSYTSSSTRVF | 99.1 | Lambda |
FA12 | IGHV1-69*01 | IGHJ4*02 | CVRALYCSSTSCYAARGGYFDYW | 98.2 | IgA1 | IGLV2-14*01 | IGLJ3*02 | CSSYTSSSTWVF | 99.1 | Lambda |
FC11 | IGHV1-18*01 | IGHJ4*02 | CAREYYDFWSGYSSYYFDYW | 99.4 | IgG1 | IGLV2-14*01 | IGLJ3*02 | CSSYTSSSTRVF | 99.7 | Lambda |
AA1 | IGHV4-4*02 | IGHJ4*02 | CARDSQQLVPFDYW | 98.2 | IgG1 | IGLV2-8*01 | IGLJ3*02 | CSSYAGSNNLRVF | 99.4 | Lambda |
FC3 | IGHV3-33*03 | IGHJ4*02 | CVREDYGIFTKFDYW | 90.5 | IgM | IGKV1-5*03 | IGKJ1*01 | CQQYNSDSWTF | 94.3 | Kappa |
GD12 | IGHV1-2*06 | IGHJ6*02 | CARDRRSSWYYYYYGMDVW | 99.14 | IgG1 | IGLV2-8*01 | IGLJ2*01 | CSSYAGSNNFRVF | 99.4 | Lambda |
GA3 | IGHV3-30-3*01 | IGHJ6*02 | CARDRSRDSSGYWLIYYYYYGMDVW | 98.2 | IgG1 | IGLV1-47*01 | IGLJ2*01 | CAAWDDSLSGVVF | 99.7 | Lambda |
EA7 | IGHV3-21*01 | IGHJ6*02 | CARGGHRVDYYYNMDVW | 96.2 | NDb | IGKV1-9*01 | IGKJ1*01 | CQQLNSYPLTF | 95.3 | Kappa |
IMGT/V-QUEST software was used to assign the germ line reference for IGHV and IGLV genes and to determine percent identity to the germ line.
ND, not determined.