Table 1.
Ex vivo expanded stem/progenitor cell transplantation studies for periodontal regeneration in clinical settings.
| Reference # | Cells | Other Materials | Stem Cells | Patient # | Defect Shape | Results (mm) Gain of LBH |
|---|---|---|---|---|---|---|
| Iwata | Periodontal Ligament Mesenchymal Stromal Cells (PDL-MSCs) | woven PGA mesh beta-TCP | yes | 10 | 8 severe defects 2 two or three-wall defects | 2.3 ± 1.8 (6M) |
| Chen | Periodontal Ligament Stem Cells (PDLSCs) | Guided Tissue Regeneration (GTR) membrane bovine-derived bone substrates | yes | 20 | - | 2.31* (3M) 2.59 *(6M) 2.71*(12M) |
| Yamada | Iliac Bone Marrow Mesenchymal Stromal Cells (BMMSCs) | Platelet-Rich Plasma (PRP) | yes | 17 | - | 3.12 ± 1.23 (12M) |
| Yamamiya | Periosteum-derived cells | PRP hydroxyapatite | unknown | 15 | 2 severe defects13 two or three-wall defects | 4.9 ± 1.2 (12M) |
Severe defects consist of one-wall intrabony defects, Class III furcation defects, and horizontal defects. *: Authors of this review calculated from the original paper. LBH; liner bone height.