Figure 1.

The structural organization of CAP1. CAP1 can be divided into three domains that are conserved across CAP homologues from species. Highlighted are the functions that are mediated by separate domains that are relevant to cell migration, largely for those important in facilitating actin dynamics. The C-terminus also binds Rap1, which can may mediate CAP1 functions in cell adhesion and proliferation. CAP1 also associates with FAK/talin to regulate those cell functions; however, the domain on CAP1 responsible for this interaction has yet to be determined, and are thus not shown here.