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. 2019 Jun 7;20(11):2787. doi: 10.3390/ijms20112787

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Fructose-induced adipogenesis through Ang-(1–7) and inhibition of thermogenesis. (A) Fructose metabolism promotes the conversion from Ang-II to Ang-(1–7) by increasing ACE2 activity. Mas receptor signaling induces the expression of adipogenic genes. (B) Sirt1 regulates the thermogenic program by inhibiting PPARγ and activating Wnt/β-catenin signalling. High fructose intake inhibits the thermogenic program by downregulating Sirt1 and UCP1 in WAT. ACE2: Angiotensin-converting enzyme 2; FAS: Fatty acid synthase; PPARϒ: Peroxisome proliferator-activated receptor ϒ; ACC: Acetyl-CoA carboxylase; aP2: Adipocyte protein 2; Sirt1: Sirtuin 1; UCP1: Uncoupling protein 1; Wnt: Wingless e Int. Created with Biorender.com.