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. 2019 May 29;20(11):2637. doi: 10.3390/ijms20112637

Figure 4.

Figure 4

Decitabine (DAC) treatment counteracts 4-hydroxy-tamoxifen (OHT) induced ERα36 expression. (a) MCF-7 cells were treated for 48 h with DMSO (as control), OHT 1 µM or by a combination OHT 1 µM/DAC 5 µM. ERα36 expression was measured by RT-qPCR analysis. (b) MCF-7 cells were transfected or not with hsa-miR-136-5p inhibitor. Both control and hsa-miR-136-5p inhibitor transfected cells were treated for 48 h by a combination of OHT 1 µM/DAC 5 µM. ERα36 expression was measured by RT-qPCR analysis. OHT treatment was used as reference. Each bar represents mean ± S.E.M. N ≥ 3. * P < 0.05.