Table 2.

Overview of immune-specific related response criteria reported in the literature.

	RECIST 1.1 [10]	irRC [11]	irRECIST [12]	iRECIST [13]
Lesion measurement	Unidimensional	Bidimensional	Unidimensional	Unidimensional
Baseline lesion size	≥10 mm	5 × 5 mm	≥10 mm	≥10 mm
Baseline lesion number	5 total, 2 per organ	10 total, 5 per organ	5 total, 2 per organ	5 total, 2 per organ
CR	Disappearance of all lesions	Disappearance of all lesions	Disappearance of all lesions	Disappearance of all lesions
PR	≥30% decrease from baseline	≥50% decrease from baseline	≥30% decrease from baseline	≥30% decrease from baseline
SD	Neither PR or PD	Neither PR or PD	Neither PR or PD	Neither PR or PD
PD	≥20% increase from nadir (≥5 mm)	≥25% increase from nadir	≥20% increase from nadir (≥5 mm)	≥20% increase from nadir (≥5 mm)
Confirmed progressive disease	Not applicable	At least 4 weeks after	At least 4 weeks after and up to 12 weeks	At least 4 weeks after and up to 8 weeks
Appearance of new lesions	Always PD	Incorporate in the sum of measurement	Incorporate in the sum of measurement	Unconfirmed progressive disease, not included in the sum of measurement

RECIST, response-evaluation criteria in solid tumors; irRC, immune-related response criteria; irRECIST, immune-related RECIST; iRECIST, immune RECIST; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.