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lncRNAs affect senescence pathways. External and internal factors trigger intracellular signaling pathways; these include MAPK, NF-kB, p53/p21, Rb/p16, IL-6/STAT3, b-catenin, and DDR. Activation of these pathways initiates cell cycle inhibition and promotes pro-senescence markers and inflammatory response. lncRNAs function at different stages either by activator or inhibitor of gene regulation.
