Table 1.

Stilbene compounds and their anticancer mechanisms by inhibition of telomerase and induction of senescence.

Stilbene Compounds	Cell Models	Target/Mechanism	Outcome	Reference
Resveratrol
RSV	U-87MG	hTERT mRNA↓	cell growth↓, cell death↑	[140]
RSV	HT-29, WiDr	Telomerase activity↓	cell proliferation↓	[141]
RSV	MCF-7	Telomerase activity↓ hTERT expression↓	S phase arrest↑ apoptosis↑	[142]
RSV	Ovaria cancer cells	hTERT expression↓ Slug↓, pScr and HIF-1α↓	EMT↓ invasion↓	[143]
Resveratrol Derivatives
RSV derivative (E)-4-(4-methoxystyryl) aniline	Colon cancer cells	hTERT expression↓ cMyc expression↓	cytotoxicity↑	[144]
RSV derivative 3,3’,4,4’,5,5’-Hexahydroxy-trans-Stilbene (M8)	Human peritoneal mesothelial cells	mitochondrial reactive oxygen species↑	senescence↑, cell cycle arrest↑	[145]
RSV sulfate metabolites	HT29, MCF-7	hTERT mRNA↓, cMyc ↓	cell death↑	[146]
Resveratrol Combined Therapy
RSV + XRT	Prostate cancer cells	p21CIP1/WAF1, p27Kip1, p53↑ Fas, TRAIL1↑, p-H2AX↑	senescence↑ apoptosis↑	[147]
RSV + IR	Lung cancer cells	ROS↑, DDR↑	senescence	[148]
RSV + quercetin	Rat glimoma cells	caspase 3/7 activation↑	senescence	[149]
RSV + 5-FU	Colon cancer cells	Telomerase activity↓ Stat3 and Akt↓	apoptosis	[150,151]
RSV + TMZ	Glioblastoma cells	Mitotic catastrophe p-ATM, p-Chk2↑	senescence↑ autophagy↑	[152]
Pterostilbene
PT	Lung cancer cells	Molecular docking to hTERT	cell death	[153]
PT	Lung cancer cells	ATM-CHK-p53	senescence↑	[154]
PT	Breast cancer cells	cMyc expression↓ hTERT expression↓	apoptosis cell cycle arrest	[155]
PT	Lung cancer cells	hTERT activity↓, hTERT expression↓, DDR↑, p53-dependent	S phase arrest↑ senescence↑	[134]
PIC	Hepatic stellate cell	p16INK4a↑, p53↑ Bcl-xl↓, SMAD↓	Inflammation↓ hepatocarcinogenesis↓	[156]