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. 2019 May 30;20(11):2664. doi: 10.3390/ijms20112664

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Phylogenetic tree of hemagglutinin (HA) sequences of A/H1N1pdm09 viruses, which was inferred by using the maximum likelihood. The percentage of replicate trees in which the associated taxa clustered together in the bootstrap test (1000 replicates) is shown next to the branches. A/H1N1pdm09 sequences originally identified in this study are reported with black circles (upper respiratory tract (URT) sample of severe cases), red/black circles (lower respiratory tract (LRT) samples of severe cases) and white circles (URT samples of mild cases). The 2017–2018 A/H1N1pdm09 vaccine strain is reported in bold and reference strains are reported in grey. Amino acid mutations are reported in red, mutations at codon 222 are in blue.