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. 2019 Jun 3;20(11):2731. doi: 10.3390/ijms20112731

Figure 4.

Figure 4

Effects of esculetin on ERK1/2, p38 MAPK, and JNK1/2 phosphorylation in collagen-activated human platelets. Washed platelets (1.2 × 109 cells/mL) were preincubated with 50 or 80 μM esculetin or 0.1% DMSO and subsequently treated with 1 μg/mL collagen to induce platelet activation. Platelets were collected and subcellular extracts were analyzed to determine the phosphorylation of (A) ERK1/2 (B) p38 MAPK, and (C) JNK1/2. Data are expressed as mean ± standard error of the mean (n = 4). ** p < 0.01 and *** p < 0.001 vs. the resting control.