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Potential effect of targeting CXCL12/CXCR4 axis in COPD. CXCR4 antagonists might act at various levels in COPD: they could promote neutrophil demargination from the lungs and inhibit T-cells and fibrocytes recruitment into bronchial tissue. CXCR4 antagonists may also contribute to maintaining the pool of hematopoeitic progenitor cells in the bone marrow, available for tissue repair. DAMPs: damage-associated molecular patterns.
