Table 1.
Physicochemical characteristics of sesquiterpene lactone loaded polylactic acid nanoparticles (PLA-NPs) (mean ± S.D., n = 3).
| Formulation | Particle Diameter (nm) | Polydispersity Index (PDI) | Zeta Potential (mV) | Encapsulation Efficiency (%) | Drug Load (%) |
|---|---|---|---|---|---|
| PLA-NP | 208.9 ± 10.5 | 0.05 ± 0.02 | −36.1± 5.4 | - | - |
| α-Santonin | 202.3 ± 8.2 | 0.03 ± 0.01 | −26.3 ± 7.8 | 94.6 ± 2.2 | 42.6 ± 8.2 |
| Arglabin | 220.3 ± 12.8 | 0.02 ± 0.00 | −35.3 ± 5.6 | 78.1 ± 7.4 | 7.5 ± 1.3 |
| Schkuhrin II | 219.5 ± 9.9 | 0.05 ± 0.01 | −35.4 ± 4.9 | 76.8 ± 3.9 | 2.5 ± 0.2 |
| Vernolepin | 216.9 ± 16.1 | 0.10 ± 0.01 | −35.3 ± 6.7 | 60.7 ± 8.9 | 0.5 ± 0.3 |
| Eucannabinolide | 226.4 ± 10.2 | 0.02 ± 0.00 | −33.5 ± 5.3 | 78.9 ± 6.3 | 2.5 ± 0.7 |