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. 2019 Jun 5;24(11):2121. doi: 10.3390/molecules24112121

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Growth inhibitory- and cytotoxic activities of compounds (A) 7d, (B) 7k, and (C) 7q across a panel of the JFCR39 cell lines. The mean graph was produced by computer processing of the 50% growth inhibition (GI₅₀) and the 50% lethal concentration (LC₅₀₎ values. The logarithm of the GI₅₀ and the LC₅₀ values for each cell line is indicated. The X-axis shows the difference on a logarithmic scale between the mean of Log GI₅₀/Log LC₅₀ values for all 39-cell lines (MG-MID, expressed as 0 in the fingerprint) and the Log GI50/Log LC₅₀ for each cell line in the JFCR39 panel. Columns to the right of 0 indicate the sensitivity of the cell lines to a given compound, and columns to the left indicate their resistance. The MG-MID mean of the Log GI₅₀/Log LC₅₀ values for all 39 cell lines; delta difference between the MG-MID and the Log GI₅₀/Log LC₅₀ value for the most sensitive cell line; range difference between the Log GI₅₀/Log LC₅₀ values for the most resistant cell line and the most sensitive cell line.

Growth inhibitory- and cytotoxic activities of compounds (A) 7d, (B) 7k, and (C) 7q across a panel of the JFCR39 cell lines. The mean graph was produced by computer processing of the 50% growth inhibition (GI₅₀) and the 50% lethal concentration (LC₅₀₎ values. The logarithm of the GI₅₀ and the LC₅₀ values for each cell line is indicated. The X-axis shows the difference on a logarithmic scale between the mean of Log GI₅₀/Log LC₅₀ values for all 39-cell lines (MG-MID, expressed as 0 in the fingerprint) and the Log GI50/Log LC₅₀ for each cell line in the JFCR39 panel. Columns to the right of 0 indicate the sensitivity of the cell lines to a given compound, and columns to the left indicate their resistance. The MG-MID mean of the Log GI₅₀/Log LC₅₀ values for all 39 cell lines; delta difference between the MG-MID and the Log GI₅₀/Log LC₅₀ value for the most sensitive cell line; range difference between the Log GI₅₀/Log LC₅₀ values for the most resistant cell line and the most sensitive cell line.