. 2019 Jun 5;24(11):2121. doi: 10.3390/molecules24112121

Table 3.

Antiproliferative activity of neocryptolepine derivatives against cell lines of the breast cancer MDA-MB-453, WiDr (colon adenocarcinoma) and SKOv3 (ovarian cancer).

Compound	MDA-MB-453 IC₅₀(μM)	WiDr IC₅₀(μM)	SKOv3 IC₅₀(μM)
Neocryptolepine	7.48 ± 4.42	N.T.	N.T.
7a	0.50 ± 0.24	0.64 ± 0.13	2.7 ± 0.42
7d	0.20 ± 0.09	0.37 ± 0.07	1.3 ± 0.18
Cisplatin	7.6 ± 0.7 ^a	8.84 ± 0.52 ^c	18.2 ± 0.1 ^d
Doxorubicin	0.086 ± 0.006 ^b	0.089 ^e	0.52

N.T.: not tested, ^a Rakic et al. (2012), ^b Sandhu et al. (2012), ^c Kuo et al. (2010), ^d Ganta et al. (2014), ^e Molphy et al. (2014).