Table 4.
Antiproliferative activity of 11-aminoalkylamino-5-methyl-indolo[2,3-b]quinolines against cell lines of MV4-11, A549 and HCT116, and cytotoxicity against normal mice fibroblast BALB/3T3 [15].
| No. | Substituent | IC50 μM | ||||
|---|---|---|---|---|---|---|
| Compounds | R1 | C11-Substituent | MV4-11 | BALB/3T3 | A549 | HCT116 |
| Cisplatin | - | 2.820 ± 0.450 | 8.700 ± 0.097 | 9.870 ± 2.400 | 8.500 ± 0.540 | |
| Doxorubicin HCl | - | 0.006 ± 0.002 | 1.078 ± 0.033 | 0.329 ± 0.097 | 0.390 ± 0.098 | |
| 2a | H | Cl | 1.312 ± 0.262 | - | - | - |
| 2b | Br | Cl | 0.810 ± 0.145 | - | - | - |
| 7l | H |
|
0.150 ± 0.060 | 4.789 ± 2.018 | 1.512 ± 0.198 | 1.262 ± 0.361 |
| 7m | Cl |
|
0.119 ± 0.043 | 9.131 ± 0.844 | 1.455 ± 0.168 | 1.373 ± 0.351 |
| 7n | Me |
|
0.105 ± 0.027 | 10.558 ± 0.330 | 1.795 ± 0.270 | 2.370 ± 0.481 |
| 7o | Cl |
|
0.103 ± 0.014 | 1.018 ± 0.017 | 1.269 ± 0.118 | 1.204 ± 0.283 |
| 7p | Br |
|
0.078 ± 0.020 | 0.939 ± 0.018 | 0.988 ± 0.164 | 0.842 ± 0.367 |