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. 2019 Jun 5;24(11):2121. doi: 10.3390/molecules24112121

Table 6.

Antiproliferative activity of the artemisinin-indoloquinoline hybrids against cell line of MV4-11, A549 and HCT116, and cytotoxicity against normal mice fibroblast BALB/3T3 [21].

Compound R1 R2 R3 MV4-11 A549 HCT116 BALB/3T3
11a Cl CH3 CH3 0.072 ± 0.022 4.555 ± 2.086 0.893 ± 0.397 6.423 ± 0.996
11b CO2Me CH3 CH3 0.075 ± 0.001 5.060 ± 0.911 2.206 ± 0.687 5.945 ± 1.163
12 CO2Me H H 0.086 ± 0.020 0.649 ± 0.080 0.130 ± 0.014 0.768 ± 0.155