Table 1.
Effect of CPD 6 on histological observations in TPA-induced acute dermatitis in mice.
| Groups | Histological Score (Mean ± S.D.) | ||
|---|---|---|---|
| Ear Edema | Epidermal Hyper Proliferation | Leucocyte Infiltration | |
| Control | 0.03 ± 0.129 | 0.03 ± 0.129 | 0.00 ± 0.000 |
| TPA | 3.33 ± 0.772 | 2.13 ± 0.767 | 2.90 ± 0.507 |
| CPD 6 (0.2 mg/ear) + TPA | 1.80 ± 0.841 ** | 1.10 ± 0.632 ** | 2.30 ± 0.21 |
| CPD 6 (0.4 mg/ear) + TPA | 1.77 ± 0.942 ** | 0.67 ± 0.645 ** | 1.83 ± 1.097 ** |
| Indo (0.2 mg/ear) + TPA | 1.27 ± 1.033 ** | 0.87 ± 0.767 ** | 1.80 ± 0.841 ** |
| CPD 6 (0.4 mg/ear) | 0.17 ± 0.244 | 0.07 ± 0.176 | 0.47 ± 0.481 |
Statistical significance was determined using a one-way ANOVA (Analysis of Variance) followed by Tukey’s test. Indo, Indomethacin; TPA, phorbol 12-myristate 13-acetate. * p < 0.05, ** p < 0.01 vs. TPA-treated group. N = 5.