Table 2.
Effect of CPD 6 on histological inflammatory observations in oxazolone-induced chronic dermatitis.
| Groups | Histological Score (mean ± S.D.) | ||
|---|---|---|---|
| Ear Edema | Epidermal Hyper Proliferation | Leucocyte Infiltration | |
| Control | 0.00 ± 0.000 | 0.00 ± 0.000 | 0.00 ± 0.000 |
| Oxaz | 4.00 ± 0.667 | 4.13 ± 0.447 | 4.8 ± 0.183 |
| CPD 6 (0.2 mg/ear) + Oxaz | 3.07 ± 0.830 | 3.07 ± 0.683 ** | 3.60 ± 1.140 * |
| CPD 6 (0.4 mg/ear) + Oxaz | 2.47 ± 0.869 ** | 2.60 ± 0.279 ** | 3.20 ± 0.558 ** |
| Dexa (0.2 mg/ear) + Oxaz | 0.67 ± 0.471 ** | 0.93 ± 0.596 ** | 0.73 ± 0.494 ** |
| CPD 6 (0.4 mg/ear) | 0.00 ± 0.000 | 0.07 ± 0.149 | 0.00 ± 0.000 |
Statistical significance was calculated using a one-way ANOVA followed by Tukey’s test. Dexa, dexamethasone; Oxaz, oxazolone. * p < 0.05 vs, ** p < 0.01 vs. Oxaz-treated group. N = 5.