Table 2.
Baseline and Follow-up Transcranial Magnetic Stimulation Measures
| Depressed Participants | ||||
|---|---|---|---|---|
| Measure | Healthy Controls, Baseline (n = 22) | Baseline (n = 15) | Follow-up (n = 10)a | P adj Valueb |
| SICI | ||||
| 2 ms | 0.45 (0.23) | 0.88 (0.39) | 1.06 (0.53) | .01 |
| 4 ms | 0.69 (0.35) | 0.98 (0.48) | 1.15 (0.62)c | .24 |
| ICF | ||||
| 10 ms | 1.47 (0.55) | 1.66 (0.53) | 1.58 (0.67) | >.99 |
| 15 ms | 1.53 (0.71) | 1.81 (0.84) | 1.49 (0.51) | .87 |
| 20 ms | 1.43 (0.66) | 1.71 (0.74) | 1.34 (0.53) | >.99 |
| LICI | ||||
| 100 ms | 0.20 (0.28) | 0.93 (2.27) | 0.31 (0.29) | >.99 |
| 150 ms | 0.32 (0.48) | 0.76 (1.30) | 0.44 (0.42) | >.99 |
| 200 ms | 1.39 (1.18) | 1.29 (1.23) | 0.60 (0.46) | >.99 |
| CSP, s | 0.18 (0.04) | 0.17 (0.05) | 0.16 (0.03) | >.99 |
Abbreviations: CDRS-R, Children’s Depression Rating Scale, Revised; CSP, cortical silent period; ICF, intracortical facilitation; LICI, long-interval intracortical inhibition; SICI, short-interval intracortical inhibition.
a Follow-up assessment timeframe: mean [SD] follow-up time, 7.9 [5.6] weeks; range, 2–20 weeks) for a subset of depressed participants treated with antidepressant medication.
b Comparison of healthy vs depressed participants at baseline. Bonferroni-corrected P values (Padj).
c For adolescents in the follow-up group, improvement in CDRS-R positively correlated with improvement in SICI-4 (P = .01; R2 = 0.63).