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. 2019 Jun 10;24(11):2182. doi: 10.3390/molecules24112182

Figure 5.

Figure 5

Effect of Lyc on rotenone-induced microglia and astrocyte activation. Immunofluorescent staining of brain tissues with Iba-1 (A) and GFAP (C) of experimental animals. Picture shows 20 µm thick sections of striatum between different groups. Densitometric assessment of fluorescent intensity was performed to quantify microglia (B) and astrocyte (D) activation using Image J. Rotenone administration caused profound increase in Iba-1 positive microglia and GFAP positive astrocyte response. Alternatively, Lyc treatment decreased the activation of microglia and astrocyte, as evinced by a decrease in Iba-1 and GFAP positive cells. Values are expressed as mean ± SEM. * p < 0.05 compared to control, # p < 0.05 compared to the rotenone-treated group.