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. 2019 Jun 27;13:1179069519856876. doi: 10.1177/1179069519856876

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — Generative potential of adult brain parenchyma.

Parenchymal astrocytes and ependymal cells have been shown to have neurogenic potential. In the steady-state brain canonical notch signalling keeps these cells in quiescence. Insults, such as stroke can block notch signalling to activate the neurogenic potential of the parenchymal astrocyte and ependymal cells. Transplantation of neural precursors grown in vitro or derived from embryonic brain can undergo neurogenic differentiation in healthy and pathogenic adult brain. HD: Huntington’s Disease, AD: Alzheimers Disease, PD: Parkinson’s Disease