Skip to main content
. 2019 Jun 6;20(11):2778. doi: 10.3390/ijms20112778

Table 1.

P2X7R modulation by stress and antidepressant treatment.

Stress/Treatment P2X7R Cell Type/Brain Structure Analysis Technique References
paroxetine ↓ BzATP-evoked inward currents cloned rat P2X7R expressed in HEK 293 cells Whole-cell patch-clamp [78]
fluoxetine or desipramine no change
paroxetine ↓ ATP-induced dye uptake recombinant human P2X7R expressed in HEK-293 cells dye uptake assay [79]
fluoxetine or clomipramine ↑ ATP-induced dye uptake
inescapable foot shocks no change ventral hippocampus of
stressed rats
WB [82]
imipramine ↓ expression
CUMS ↑ expression hippocampus of
stressed mice
WB [80]
clemastine ↓ expression
chronic restraint stress ↑ expression hippocampus of stressed mice WB [81]
ketamine ↓ expression
CUS no change hippocampus of stressed rats IHC [53]
Acute or chronic restraint stress ↓ expression hippocampus of stressed rats IHC [83]

ATP: adenosine triphosphate; BzATP: 3’-O-(4-benzoyl)benzoyl-ATP; HEK: human embryonic kidney; WB: western blotting; CUMS: chronic unpredictable mild stress; IHC: immunohistochemistry.