Table 1.

P2X7R modulation by stress and antidepressant treatment.

Stress/Treatment	P2X7R	Cell Type/Brain Structure	Analysis Technique	References
paroxetine	↓ BzATP-evoked inward currents	cloned rat P2X7R expressed in HEK 293 cells	Whole-cell patch-clamp	[78]
fluoxetine or desipramine	no change
paroxetine	↓ ATP-induced dye uptake	recombinant human P2X7R expressed in HEK-293 cells	dye uptake assay	[79]
fluoxetine or clomipramine	↑ ATP-induced dye uptake
inescapable foot shocks	no change	ventral hippocampus of stressed rats	WB	[82]
imipramine	↓ expression
CUMS	↑ expression	hippocampus of stressed mice	WB	[80]
clemastine	↓ expression
chronic restraint stress	↑ expression	hippocampus of stressed mice	WB	[81]
ketamine	↓ expression
CUS	no change	hippocampus of stressed rats	IHC	[53]
Acute or chronic restraint stress	↓ expression	hippocampus of stressed rats	IHC	[83]

ATP: adenosine triphosphate; BzATP: 3’-O-(4-benzoyl)benzoyl-ATP; HEK: human embryonic kidney; WB: western blotting; CUMS: chronic unpredictable mild stress; IHC: immunohistochemistry.