Table 1.
P2X7R modulation by stress and antidepressant treatment.
Stress/Treatment | P2X7R | Cell Type/Brain Structure | Analysis Technique | References |
---|---|---|---|---|
paroxetine | ↓ BzATP-evoked inward currents | cloned rat P2X7R expressed in HEK 293 cells | Whole-cell patch-clamp | [78] |
fluoxetine or desipramine | no change | |||
paroxetine | ↓ ATP-induced dye uptake | recombinant human P2X7R expressed in HEK-293 cells | dye uptake assay | [79] |
fluoxetine or clomipramine | ↑ ATP-induced dye uptake | |||
inescapable foot shocks | no change | ventral hippocampus of stressed rats |
WB | [82] |
imipramine | ↓ expression | |||
CUMS | ↑ expression | hippocampus of stressed mice |
WB | [80] |
clemastine | ↓ expression | |||
chronic restraint stress | ↑ expression | hippocampus of stressed mice | WB | [81] |
ketamine | ↓ expression | |||
CUS | no change | hippocampus of stressed rats | IHC | [53] |
Acute or chronic restraint stress | ↓ expression | hippocampus of stressed rats | IHC | [83] |
ATP: adenosine triphosphate; BzATP: 3’-O-(4-benzoyl)benzoyl-ATP; HEK: human embryonic kidney; WB: western blotting; CUMS: chronic unpredictable mild stress; IHC: immunohistochemistry.