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. 2019 May 30;20(11):2652. doi: 10.3390/ijms20112652

Figure 1.

Figure 1

Effects of AhR ligands on CYP1A1, CYP1B1, AhRR, cytokines, and IDO expression in BMM. The mRNA expression of (A) CYP1A1, CYP1B1, and AhRR induced by AhR ligands in BMM is shown. BMM derived from wt or RelB−/− mice were treated with 1 nM TCDD, 100 nM FICZ, or 50 μM I3C for 24 h. Results from real-time PCR are presented as mean ± SEM and the y-axis represents mRNA expression level as fold increase above control. a significantly higher than BMM control, p < 0.05; b significantly lower than TCDD- or FICZ-treated wt or RelB−/− BMM, p < 0.05; c significantly lower than wt BMM, p < 0.05. (B) Expression of IL-17A and IL-22 in BMM derived from wt or RelB−/− mice treated with 1 nM TCDD, 100 nM FICZ, or 50 μM I3C for 24h in the absence or presence of LPS (50 ng/mL). a significantly higher than wt BMM control, p < 0.05; b significantly higher than FICZ- or LPS-treated wt BMM, p < 0.05; c significantly lower than wt BMM, p < 0.05. (C) Expression of CCL20, IL-6, and IL-10 in BMM derived from wt or RelB−/− mice treated with 1 nM TCDD, 100 nM FICZ, or 50 μM I3C for 24 h in the presence of LPS (50 ng/mL). a significantly higher than BMM control, p < 0.05; b significantly higher than LPS-treated BMM, p < 0.05; c significantly lower than LPS, TCDD, or FICZ-treated BMM, p < 0.05; d significantly lower than wt BMM, p < 0.05. (D) Expression of IDO1 and IDO2 in BMM derived from wt or RelB−/− mice treated with 1 nM TCDD, 100 nM FICZ, or 50 μM I3C for 24 h in the presence or absence of LPS (50 ng/mL). a significantly higher than BMM control, p < 0.05; b significantly higher than LPS-treated BMM, p < 0.05.