Table 1.
Mean level of three-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) adducts, expressed as a relative adduct level (RAL) per 108 normal nucleotides (nn), Mean Ratio (MR), and 95% Confidence Interval (C.I.), by exposure to wood dust and other variables.
| M1dG, Smoking Habits, Exposure to Wood Dust, and Occupational History | ||||
|---|---|---|---|---|
| N | RAL Per 108 nn ± Standard Error | Mean Ratio and 95% C.I. | p-Value a | |
| Smoking habits | ||||
| Non-smokers | 111 | 63.7 ± 4.7 | 1 | |
| Former smokers | 36 | 68.7 ± 9.6 | 0.97 (95% C.I. 0.73–1.31) | 0.873 |
| Current smokers | 76 | 81.0 ± 8.5 | 1.17 (95% C.I. 0.92–1.48) | 0.190 |
| Exposure to wood dust | ||||
| Controls | 87 | 50.4 ± 2.7 | 1 | |
| Woodworkers | 136 | 83.2 ± 6.2 | 1.28 (95% C.I. 1.03–1.58) | 0.021 |
| Occupational history | ||||
| ≤ 8 years | 40 | 67.9 ± 15.1 | 1 | |
| 9–25 years | 49 | 79.0 ± 8.8 | 1.67 (95% C.I. 1.16–2.38) | 0.005 |
| ≥ 26 years | 47 | 100.6 ± 8.2 | 2.47 (95% C.I. 1.67–3.62) | <0.001 |
ap-values (Test of Wald) were adjusted for age and smoking, as appropriate.