Table 2.
Average level of three-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG), expressed as relative adduct level (RAL) per 108 normal nucleotides, Mean Ratio (MR), and 95% Confidence Interval (C.I.), by smoking habits and occupational status, i.e., exposure to wood dust alone and co-exposure to volatile organic compounds (VOCs).
| M1dG, Exposure to Wood Dust (Alone), and Co-Exposure to VOCs | ||||
|---|---|---|---|---|
| N | RAL per 108 nn ± Standard Error | Mean Ratio and 95% C.I. | p-Value a | |
| Non-smokers | ||||
| Controls | 50 | 45.5 ± 3.4 | 1 | |
| Workers exposed to wood dust (alone) | 48 | 78.8 ± 8.6 | 1.43 (95% C.I. 1.09–1.87) | 0.009 |
| Woodworkers exposed to VOCS | 13 | 80.3 ± 17.5 | 1.59 (95% C.I. 1.05–2.43) | 0.027 |
| Former smokers | ||||
| Controls | 11 | 50.9 ± 6.3 | 1 | |
| Workers exposed to wood dust (alone) | 17 | 67.2 ± 16.8 | 0.93 (95% C.I. 0.48–1.78) | 0.829 |
| Woodworkers exposed to VOCS | 8 | 96.6 ± 21.1 | 1.52 (95% C.I. 0.71–3.26) | 0.211 |
| Current smokers | ||||
| Controls | 26 | 59.8 ± 5.1 | 1 | |
| Workers exposed to wood dust (alone) | 34 | 60.8 ± 8.1 | 0.78 (95% C.I. 0.58–1.14) | 0.211 |
| Woodworkers exposed to VOCS | 16 | 158.4 ± 29.3 | 2.33 (95% C.I. 1.45–3.70) | 0.0003 |
ap-values (Test of Wald) were adjusted for age.