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Scheme of the preparation of a VHH based immunoadsorbent: (a) 1,4-butanediol diglycidyl and (b) 3,3′-diaminodipropylamine were used to prepare the amino-activated matrix based on the CL-6B agarose beads. Aldehyde-modified VHHs were then coupled to the matrix via the reductive amination.
