Figure 3.

At 3 months, platelet-rich plasma (PRP) demonstrated a statistically but not clinically significant reduction in pain compared with controls across all indications. Subgroup analysis by clinical indication, and comparator where there were multiple trials, revealed that PRP outperformed placebo and steroid both statistically and clinically for knee osteoarthritis only. The remaining subgroups either had CIs that overlapped thresholds for minimally important difference (red line = standardized mean difference [SMD] 0.5) or statistical significance (black line = SMD 0); or were composed of only a single study. Pooled estimates by indication are in navy, with comparator subgroups in light blue. Estimates for indications with only single trials (gray) are found at the bottom; p int, p interaction for subgroup effects.