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A diagrammatic representation of steps in the formation of irreversible advanced glycation end products. Letters A to D denote sites where AGEs formation could be intervened through lifestyle changes or use of pharmacologic agents. A, Schiff’s base formation leading to glycation; B, Rearrangement of glycated proteins into Amadori adducts; C, Cross-linking of Amadori adducts into irreversible AGEs; D, Conversion of glycated products into reactive dicrbonyl compounds.
