Table 2.
Authors | Number of patients | Dose of rituximab | Follow‐up | Outcome |
---|---|---|---|---|
Sonnenday et al60 | 6 | 375 mg/m2, single dose | 12 mo | Mean SCR. was 1.3 ± 0.1 mg/dL |
No episodes of AMR | ||||
Stable allograft function | ||||
Genberg et al61 | 15 | 375 mg/m2, single dose | 3 y | 100% patient survival |
87% overall graft survival | ||||
Acute rejection in 1 patient | ||||
Sivakumaran et al62 | 10 | 375 mg/m2, single dose | 1 y | 100% patient survival |
Mean SCr = 1.45 ± 1.04 mg/dL | ||||
4 episodes of AMR | ||||
2 incidents of DGF | ||||
Genberg et al63 | 43 | 375 mg/m2, single dose | 4.5 y | 93% overall patient survival |
91% graft survival | ||||
9.3% incidence of AMR | ||||
Melexopoulou et al64 | 30 | 375 mg/m2, single dose | 6 y | 92% patient survival |
81% graft survival | ||||
No CAMR | ||||
13.3% ACR | ||||
Jha et al65 | 20 | 200 mg, single dose | 90% patient survival | |
95% graft survival | ||||
15% AMR | ||||
Lee et al66 | 59 | 375 mg/m2, or 200 mg single dose | 2 y | 95.8% patient survival |
94.9% graft survival | ||||
15.3% AMR | ||||
1 graft loss | ||||
Kong et al67 | 79 | 53% patients mean 644 ± 226 mg/body47% patients 203 ± 14 mg/body | 21 mo | 99.2% patient survival |
97.5% graft survival | ||||
14% patients had acute rejection | ||||
Rostaing et al68 | 12 | 375 mg/m2, two dose | 19 mo | 91.6% graft survival |
100% patient survival | ||||
3 patient had CAMR | ||||
58.3% showed nearly normal kidney biopsy | ||||
Ray et al69 | 45 | 200 mg/body single infusion | 370 d | Mean SCr = 1.21 mg% |
97.78% graft survival | ||||
97.78% patient survival |
ACR, acute cellular rejection; AMR, antibody‐mediated rejection; CAMR, chronic antibody‐mediated rejection; DGF, delayed graft function; SCR, serum creatinine.