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. 2019 Mar 26;2(2):76–82. doi: 10.1002/ame2.12064

Table 2.

Results from adult ABOi renal transplant programs using rituximab

Authors Number of patients Dose of rituximab Follow‐up Outcome
Sonnenday et al60 6 375 mg/m2, single dose 12 mo Mean SCR. was 1.3 ± 0.1 mg/dL
No episodes of AMR
Stable allograft function
Genberg et al61 15 375 mg/m2, single dose 3 y 100% patient survival
87% overall graft survival
Acute rejection in 1 patient
Sivakumaran et al62 10 375 mg/m2, single dose 1 y 100% patient survival
Mean SCr = 1.45 ± 1.04 mg/dL
4 episodes of AMR
2 incidents of DGF
Genberg et al63 43 375 mg/m2, single dose 4.5 y 93% overall patient survival
91% graft survival
9.3% incidence of AMR
Melexopoulou et al64 30 375 mg/m2, single dose 6 y 92% patient survival
81% graft survival
No CAMR
13.3% ACR
Jha et al65 20 200 mg, single dose   90% patient survival
95% graft survival
15% AMR
Lee et al66 59 375 mg/m2, or 200 mg single dose 2 y 95.8% patient survival
94.9% graft survival
15.3% AMR
1 graft loss
Kong et al67 79 53% patients mean 644 ± 226 mg/body47% patients 203 ± 14 mg/body 21 mo 99.2% patient survival
97.5% graft survival
14% patients had acute rejection
Rostaing et al68 12 375 mg/m2, two dose 19 mo 91.6% graft survival 
100% patient survival 
3 patient had CAMR
58.3% showed nearly normal kidney biopsy
Ray et al69 45 200 mg/body single infusion 370 d Mean SCr = 1.21 mg%
97.78% graft survival 
97.78% patient survival 

ACR, acute cellular rejection; AMR, antibody‐mediated rejection; CAMR, chronic antibody‐mediated rejection; DGF, delayed graft function; SCR, serum creatinine.