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. 2019 May 22;38(13):e101174. doi: 10.15252/embj.2018101174

Figure 5. The total abundance of RPL23 and histone H4 is altered in K3 mice and human FTD brains.

Figure 5

  1. The total abundance of RPL23 is decreased in K3 mice compared with WT controls at both 2 and 5 months of age. RPL23, FUNCAT and MAP2 signal intensities are decreased in layer 2/3 cortical neurons of K3 mice in an age‐dependent manner (two‐way ANOVA, Sidak's multiple comparison test, n = 3 animals).
  2. Histone H4 levels are increased in layer 2/3 of the cortex of K3 compared with WT mice at 5 months of age. This difference is not observed at 2 months of age (two‐way ANOVA, Sidak's multiple comparison test, n = 3 animals).
  3. Levels of RPL23 are significantly decreased in neurons from the superior frontal cortex of human FTD brains compared with healthy controls. This decrease correlates with AT8 tau (Spearman's correlation, ρ = −0.4681, standard error of correlation represented by black dots, Student's t‐test, n > 3, ≥ 15 neurons per sample).
  4. Histone H4 levels are significantly increased in neurons from the superior frontal cortex of human FTD brains compared with healthy controls (Student's t‐test, n = 3, ≥ 15 neurons per sample). This increase is not correlated with AT8 (Pearson's correlation r 2 = 0.0063, standard error of correlation represented by black dots).
Data information: Mean ± SEM. **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. Scale bar: 40 μm.