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. 2019 Jun 4;24(11):2109. doi: 10.3390/molecules24112109

Figure 1.

Figure 1

Effects of CrataBL on the cell viability and cells death of MSCs, U87 cells, and cocultured cells. Cell viability was measured by MTT assay at increasing concentrations of the inhibitor CrataBL at 5 µM, 25 µM, 50 µM, and 100 μM concentrations after 24 and 48 h of treatment. The absorbance values were normalized to nontreated control cells (c), as described in the Methods section. Panels represent (A) MSC, U87 glioblastoma cells, and direct cocultures. Cell death (B) was evaluated by flow cytometry as described in the Methods section, in MSC, U87 cells and cocultures after 24 h of CrataBL treatment. AN/PI represent viable cells; AN+/PI represent early apoptotic; AN+/PI+ and AN/PI+ represent late apoptotic and necrotic cells. Significance among experimental groups was considered as * p < 0.05, ** p < 0.005, and *** p < 0.0005.