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The effects of honokiol on the metabolites of the tryptophan–kynurenine (TRP–KYN) pathway. (A) serotonin (5-HT); (B) TRP; (C) KYN; (D) kynurenic acid (KYNA); (E) quinolinic acid (QUIN); (F) KYN/TRP ratio; and (G) KYN/KYNA ratio. Data are expressed as mean ± SEM (n = 5). ## p < 0.01, # p < 0.05 LPS vs. control; * p < 0.05 LPS + Honokiol vs. LPS.
