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Pharmacokinetic parameters of DX-03-12 after a single oral or intravenous dose in male ICR mice.
| Parameters | Units | PO 30 mg/kg |
iv 3 mg/kg |
|---|---|---|---|
| t1/2β | h | 4.61 | 3.49 |
| Tmax | h | 1 | 0.033 |
| Cmax | ng/mL | 2963 | 2138 |
| AUC(0-t) | h*ng/mL | 12,902 | 1346 |
| AUC(0-∞) | h*ng/mL | 13,094 | 1500 |
| Vss | L/kg | - | 10.1 |
| Cl | mL/min/kg | - | 33.3 |
| F% | 96 | - |
