Aβ |
amyloid-β |
AβO |
amyloid-β oligomer |
PS1 |
presenilin 1 |
eIF2α |
eukaryotic translation initiation factor 2α |
GADD34 |
growth arrest and DNA damaged-inducible gene 34 |
ATF4 |
activating transcription factor 4 |
AD |
Alzheimer’s disease |
APP |
Aβ precursor protein |
ER |
endoplasmic reticulum |
PKR |
double-stranded RNA-activated protein kinase |
PERK |
PKR-like ER-localized eIF2α kinase |
GCN2 |
general control nonderepressible-2 |
HRI |
heme-regulated inhibitor |
CREB2 |
cAMP response element binding protein 2 |
ISR |
integrated stress response |
GTP |
guanosine triphosphate |
PP1c |
protein phosphatase 1c |
CReP |
constitutive repressor of eIF2α phosphorylation |
ApoE |
apolipoprotein E |
Atg5 |
autophagy-related 5 |
ISRIB |
ISR inhibitor |
GEF |
guanine nucleotide exchange factor |
NSCs |
neural stem cells |
SVZ |
subventricular zone |
SGZ |
hippocampal subgranular zone |
iPSCs |
induced pluripotent stem cells |
REST |
repressor element 1-silencing transcriptional factor |
BDNF |
brain-derived neurotrophic factor |
FNDC5 |
fibronectin type III domain-containing protein 5 |
DCX |
doublecortin |
LV |
lateral ventricle |
MCI |
mild cognitive impairment |
IRE1 |
inositol-requiring enzyme 1 |
XBP1 |
X-box binding protein 1 |