Table 4.
DNA methylation, rs1360780 and percentage reduction in CGI severity
| Post‐treatment | Follow‐up | Pre‐Post‐treatment, outcome at follow‐up | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Region | β | CI (95%) | p | β | CI (95%) | p | β | CI (95%) | p | |
| Intron 7 | CpG 1 | 1.44 | −1.40–4.27 | .322 | −0.36 | −3.12–2.40 | .798 | −0.28 | −3.71–3.15 | 0.875 |
| rs1360780 | −0.04 | −0.45–0.37 | .849 | 0.11 | −0.35–0.58 | .638 | 0.17 | −0.29–0.62 | 0.476 | |
| Interaction | −1.09 | −5.22–3.04 | .606 | −0.17 | −4.42–4.08 | .937 | 1.72 | −2.92–6.36 | 0.467 | |
| CpG 2 | 0.6 | −1.35–2.55 | .546 | 0.79 | −1.47–3.06 | .493 | 1.95 | −0.07–3.96 | 0.058 | |
| rs1360780 | −0.06 | −0.47–0.34 | .764 | 0.04 | −0.42–0.51 | .851 | 0.03 | −0.40–0.46 | 0.877 | |
| Interaction | −0.29 | −3.46–2.89 | .860 | −0.65 | −4.37–3.08 | .734 | −2.36 | −5.62–0.89 | 0.155 | |
| CpG 3 | −0.19 | −1.10–0.72 | .685 | −0.93 | −1.85–0.01 | .049 | −0.57 | −1.55–0.42 | 0.258 | |
| rs1360780 | −0.17 | −0.54–0.21 | .382 | −0.06 | −0.46–0.35 | .773 | −0.11 | −0.50–0.28 | 0.576 | |
| Interaction | −0.45 | −2.09–1.18 | .586 | 0.015 | −1.50–1.53 | .984 | −0.77 | −2.36–0.82 | 0.342 | |
| CpG 4 | 1.57 | −1.09–4.24 | .248 | −1.06 | −2.59–0.47 | .176 | 1.29 | −1.93–4.51 | 0.431 | |
| rs1360780 | −0.13 | −0.51–0.25 | .503 | 0.09 | −0.35–0.53 | .696 | −0.06 | −0.49–0.37 | 0.793 | |
| Interaction | −4.27 | −8.87–0.33 | .069 | 1.56 | −1.12–4.25 | .254 | −0.40 | −5.55–4.75 | 0.878 | |
| CpG 5 | −0.98 | −3.27–1.30 | .400 | −1.93 | −3.76–0.09 | .040 | −4.26 | −6.62–1.90 | 4.10E‐04 | |
| rs1360780 | 0.03 | −0.37–0.43 | .876 | 0.03 | −0.40–0.45 | .902 | 0.2 | −0.20–0.60 | 0.333 | |
| Interaction | 0.06 | −2.90–3.02 | .967 | 0.67 | −2.14–3.48 | .641 | 2.73 | −0.33–5.80 | 0.080 | |
| Bin 2 | 1.02 | −1.03–3.08 | .725 | −1.34 | −2.92–0.24 | .098 | −0.71 | −3.14–1.72 | 0.566 | |
| rs1360780 | −0.13 | −0.49–0.22 | .468 | 0.05 | −0.38–0.49 | .814 | −0.02 | −0.44–0.40 | 0.920 | |
| Interaction | −2.37 | −5.76–1.03 | .172 | 0.12 | −3.14–3.37 | .945 | −1.39 | −5.28–2.51 | 0.485 | |
| Promoter | CpG 1 | 2.02 | 0.48–3.55 | .010 | −0.41 | −2.01–1.19 | .616 | 0.79 | −1.10–2.67 | 0.413 |
| rs1360780 | −0.06 | −0.41–0.29 | .728 | −0.07 | −0.45–0.31 | .715 | −0.04 | −0.43–0.35 | 0.850 | |
| Interaction | −0.63 | −2.85–1.59 | .578 | 0.88 | −1.27–3.02 | .423 | 0.15 | −2.45–2.75 | 0.909 | |
| CpG 2 (11) | 0.48 | −0.75–1.70 | .446 | −0.65 | −1.97–0.68 | .340 | −0.39 | −1.72–0.94 | 0.564 | |
| rs1360780 | −0.17 | −0.51–0.17 | .336 | −0.13 | −0.50–0.25 | .510 | −0.13 | −0.52–0.25 | 0.495 | |
| Interaction | 0.69 | −1.11–2.49 | .452 | 1.27 | −0.92–3.47 | .255 | 2.03 | 0.06–4.02 | 0.044 | |
N.B Values in bold are nominally significant. Highlighted values are significant after correction for multiple testing.