Table 3.
Acupuncture in the Treatment of Cognitive Impairment and Depression After Stroke: Overview of Meta-Analyses Results
| First author and year of publication | Comparison | Time of assessment | No. of studies (no. of patients) | Pooled results (95%CI) | Heterogeneity I2 (%) |
|---|---|---|---|---|---|
| The overview of meta-analysis result of acupuncture in the treatment of cognitive impairment after stroke | |||||
| Change of Mini-mental state examination (MMSE) total scores | |||||
| Liu, 201442 | Acupuncture + cognitive rehabilitation/conventional intervention vs. cognitive rehabilitation/conventional intervention | After 4 weeks treatment | 4 (232) | Pooled WMD: 3.14 (2.06, 4.21) | 36 |
| Liu, 201442 | Acupuncture + cognitive rehabilitation/conventional intervention vs. cognitive rehabilitation/conventional | After 8 weeks treatment | 3 (128) | Pooled WMD: 2.03 (0.26, 3.80) | 72 |
| Liu, 201562 | Electro-acupuncture + cognitive rehabilitation/conventional intervention vs. cognitive rehabilitation/conventional | After 4–8 weeks treatment | 8 (NA) | Pooled WMD: 2.12 (0.16, 4.08) | 95 |
| Xiong, 201664 | Scalp acupuncture + cognitive rehabilitation/conventional intervention vs. cognitive rehabilitation/conventional | After 8–12 weeks treatment | 10 (732) | Pooled WMD: 2.22 (1.38, 3.07) | 76 |
| Zhang, 201563 | Acupuncture/moxibustion + cognitive rehabilitation vs. cognitive rehabilitation | After 4 weeks treatment | 3 (208) | Pooled WMD: 3.22 (2.09, 4.34) | 0 |
| Zhang, 201563 | Acupuncture/moxibustion + cognitive rehabilitation vs. Nimodipin | After 4–8 weeks treatment | 2 (175) | Pooled WMD: 1.84 (0.51, 3.16) | 0 |
| Zhang, 201563 | Acupuncture/moxibustion + cognitive rehabilitation vs. cognitive rehabilitation/Nimodipin | After 4–8 weeks treatment | 5 (383) | Pooled WMD: 2.64 (1.78, 3.50) | 0 |
| Change of Activities of Daily Living (ADL) scales | |||||
| Zhang, 201563 | Acupuncture/moxibustion + cognitive rehabilitation vs. cognitive rehabilitation | After 4 weeks to 3 months treatment | 4 (249) | Pooled WMD: 0.62 (0.36, 0.88) |
46 |
| Zhang, 201563 | Acupuncture/moxibustion + cognitive rehabilitation vs. cognitive rehabilitation/conventional intervention | After 4 weeks to 3 months treatment | 6 (364) | Pooled WMD: 0.52 (0.31, 0.73) | 46 |
| The overview of meta-analysis result of acupuncture in the treatment of post stroke depression | |||||
| Change of Hamilton Rating Scale for Depression (HAMD) (17 items) | |||||
| Que, 201870 | Acupuncture vs. antidepressants (Fluoxetine) | After 4 weeks treatment | 4 (270) | Pooled WMD: −3.29 (−6.87, 0.29) | 95 |
| Que, 201870 | Acupuncture vs. antidepressants (Fluoxetine) | After 4–6 weeks treatment | 5 (313) | Pooled WMD: −2.84 (−6.04, 0.36) | 93 |
| Zhang, 201466 | Acupuncture vs. antidepressants (Fluoxetine) | After 2 weeks treatment | 4 (192) | Pooled WMD: −2.34 (−3.46, −1.22) | 5 |
| Change of HAMD (24 items) | |||||
| Que, 201870 | Acupuncture vs. antidepressants (Fluoxetine) | After 8 weeks treatment | 2 (531) | Pooled WMD: −3.17 (−6.16, −0.18) | 96 |
| Que, 201870 | Acupuncture vs. antidepressants (Fluoxetine) | After 4 weeks treatment | 4 (268) | Pooled WMD: −1.42 (−3.45, 0.61) | 79 |
| Que, 201870 | Acupuncture vs. antidepressants (Fluoxetine) | After 4–8 weeks treatment | 7 (919) | Pooled WMD: −2.58 (−4.06, −1.09) | 90 |
| Xiong, 201067 | Acupuncture vs. antidepressants (Fluoxetine) | After 4 weeks treatment | 7 (458) | Pooled WMD: −1.34 (−2.67, −0.02) | 69 |
| Zhang, 201466 | Acupuncture vs. antidepressants (Fluoxetine) | After 4 weeks treatment | 7 (382) | Pooled WMD: −0.49 (−1.72, 0.74) | 52 |
| HAMD (24 items) reduction rate | |||||
| Niu, 201469 | Electro-acupuncture vs. antidepressants (Fluoxetine) | After 4 weeks treatment | 6 (358) | Pooled OR: 1.57 (0.78, 3.16) | 0 |
| Niu, 201469 | Electro-acupuncture vs. antidepressants (Fluoxetine) | After 8 weeks treatment | 5 (527) | Pooled OR: 1.72 (1.05, 2.28) | 0 |
| Niu, 201469 | Electro-acupuncture vs. antidepressants (Fluoxetine) | After 4–8 weeks treatment | 12 (946) | Pooled OR: 1.61 (1.09, 2.38) | 0 |
| Xiong, 201067 | Acupuncture vs. antidepressants | After 1–8 weeks treatment | 5 (595) | Pooled RR: 1.15 (1.07, 1.24) | 24 |
| Zhang, 201466 | Acupuncture vs. antidepressants (Fluoxetine) | After 4 weeks treatment | 8 (422) | Pooled RR: 1.11 (1.03, 1.21) | 0 |
| Zhang, 201466 | Acupuncture vs. antidepressants | After 6 weeks treatment | 3 (183) | Pooled RR: 1.10 (0.94, 1.28) | 40 |
| Incidence of adverse event | |||||
| Li, 201874 | Electro-acupuncture vs. antidepressants | After 4–8 weeks treatment | 8 (798) | Pooled RR: 0.21 (0.14,0.33) | 0 |
| Que, 201870 | Acupuncture vs. antidepressants (Fluoxetine) | After 4–8 weeks treatment | 9 (628) | Pooled OR: 0.10 (0.05,0.19) | 42 |
| Zhang, 201465 | Acupuncture vs. antidepressants | After 4 weeks treatment | 8 (502) | Pooled RR: 0.32 (0.19, 0.53) | 0 |