Figure 5. Electrophysiological activity in KNDy neurons is tightly correlated with discharges of luteinizing hormone in mouse.

High-fidelity correlation between electrophysiological activity (reflected by intracellular Ca ⁺⁺) of kisspeptin (KNDy) neurons in the arcuate nucleus of gonadectomized male mice monitored in vivo using an optogenetic approach (black trace) and the pulsatile secretion of luteinizing hormone (LH) (red) as tracked by measuring plasma concentrations of the gonadotropin. Reproduced from Clarkson et al. ⁵⁷ with permission from the National Academy of Sciences.