Table 1.

Summary of the ten targets investigated.

Target	Protein Family	Species	N	Drug Stage
Anaplastic lymphoma kinase (ALK)	Receptor Tyr Kinase	H. sapiens	1343	Phase IV
Aurora B	Ser/Thr Kinase	H. sapiens	1481	Phase III
β-2 Adrenergic Receptor	GPCR	H. sapiens	641	Phase IV
c-Abl	Tyr Kinase	H. sapiens	1439	Phase IV
Factor Xa	Protease	H. sapiens	1657	Phase IV
HIV Protease	Protease	HIV	2544	Phase IV
JAK2	Non-receptor Tyr Kinase	H. sapiens	3624	Phase IV
MEK1	MAP Kinase Kinase	H. sapiens	823	Phase IV
PARP1	Polymerase	H. sapiens	1933	Phase IV
TYRO3	Receptor Tyr Kinase	H. sapiens	277	none