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Performance statistics for RFs with retained predictivity generated with the specified error in each split.
| Model | %Error Before Failure | ROC AUC | Top 10% Mean IC50 (nM) | Mean IC50 (nM) | Bottom 10% Mean IC50 (nM) | Fold Difference in Mean Top 10% IC50 |
|---|---|---|---|---|---|---|
| ALK < 20 nM RF | Control | 0.913 | 3.33 | 4200 | 16,000 | 4800 |
| Split 1 Pre-failure | 25 | 0.828 | 362 | 4200 | 6400 | 18 |
| Split 2 Pre-failure | 35 | 0.739 | 111 | 3300 | 5600 | 50 |
| Split 3 Pre-failure | 35 | 0.746 | 19.5 | 4100 | 7600 | 390 |
