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Performance statistics for PNNs with retained predictivity generated with the specified error in each split.
| Model | %Error Before Failure | ROC AUC | Top 10% Mean IC50 (nM) | Mean IC50 (nM) | Bottom 10% Mean IC50 (nM) | Fold Difference in Mean Top 10% IC50 |
|---|---|---|---|---|---|---|
| ALK < 20 nM PNN | Control | 0.782 | 34.7 | 4200 | 19,000 | 550 |
| Split 1 Pre-failure | 15 | 0.701 | 14.0 | 4200 | 2700 | 190 |
| Split 2 Pre-failure | 25 | 0.706 | 637 | 3300 | 5500 | 8.6 |
| Split 3 Pre-failure | 10 | 0.736 | 375 | 4100 | 7400 | 20 |
