Table 1.
Summary of Innate Lymphoid Cell subsets and function.
| Group | Subsets | Transcription Factor Expression | Co-receptor Expression | Cytokine/Alarmins Stimulation | Effector Cytokine Profile | Role Within the Immune System |
|---|---|---|---|---|---|---|
| Group 1 ILC | NK Cells (CD49b+) ILC1(Lin−CD127+/-CD49a+) |
Tbet+EOMES+ Tbet+ |
PD-1 CTLA4 |
IL-15 IL-12 IL-18 |
IFNγ TNFα Perforin and granzyme (NK cells) |
Viral defence Anti-Tumour defence Intestinal inflammation |
| Group 2 ILC | Natural (ST2+, IL33R+) Inflammatory (KLRG1+) Mature (ST2+KLRG1+) |
GATA3+ | PD-1 CTLA4 ICOS (PDL-1) (OX40L) |
IL-25 IL-33 TSLP |
IL-4 IL-5 IL-13 Amphregulin |
Helminth defence Thermogenesis Tissue repair Allergy Atopic dermatitis |
| Group 3 ILC | NCR+ (Nkp46+/Nkp44+) NCR− (Nkp46−/Nkp44−) LTi |
RORγt+ | PD-1 CTLA4 |
IL-23 IL-1β |
IL-17 IL-22 GM-CSF |
Intestinal homeostasis Bacterial defence Colitis Psorasis Colon Cancer |